PAI-1 is a primary regulator of fibronlysis. It is found in many tissues and cell types including macrophages / monocytes, hepatocytes, vascular endothelia, adipose tissue of the heart and lungs and in platelets. The amount of PAI-1 in plasma is related to various thrombotic and fibrinolytic complications.
A lack of PAI-1 activity is linked to bleeding disorders wherein routine hemostatic screening tests are normal. High levels of PAI-1 activity are present in patients who suffers from myocardial infarction, haemolytic uremic syndrome and stroke.
» Measures active and latent forms of PAI-1 and tPA/PAI-1 complexes
» 96 tests per kit