ADAMTS13 is a metalloproteinase that cleaves ultra large (UL) vWF multimers within the A2 region of vWF.
Research have shown that low levels of ADAMTS13 activity are associated with TTP (Thrombotic Thrombocytopenia Purpura); a serious life threatening hematological illness characterized by low platelet count, microvascular thrombi, red cell fragmentation, CNS and renal complications.
