Ristocetin CoFactor is the in vitro activity of von Willebrand Factor which is measured by the agglutination of platelets in the presence of Ristocetin. Decreased von Willebrand Factor is associated with the von Willebrand Syndrome, thus making quantification of the Ristocetin CoFactor activity most valuable in the diagnosis and evaluation of this coagulopathy. Levels of this Ristocetin CoFactor activity are determined by the ability of the test plasma and Ristocetin to induce the agglutination of a standardized platelet suspension.
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