ADAMTS13 is a metalloproteinase that cleaves ultra large (UL) vWF multimers within the A2 region of vWF.
Research has shown that low levels of ADAMTS13 activity are associated with TTP (Thrombotic Thrombocytopenia Purpura); a serious life threatening hematological illness characterized by low platelet count,microvascular thrombi, red cell fragmentation, CNS and renal complications.
